Institutional Review Boards and Vulnerable Populations

Institutional review boards (IRBs), consist of, at least a 5 member team responsible in reviewing the clinical trial rationale and all the essential plan related to a trial.  The main objectives of an IRB, is to review all protocols, investigate the investigator and evaluate the risk-benefit assessment of human subject participant’s enrollment in a clinical trial. Their objective is to ensure that human subjects are protected, and in no way, in an unnecessary higher risk, in an experiment, before and after a clinical study (Wood, & Markel, 2012).  Also, IRB is responsible in reviewing the scientific rationale and the applicable methodology for the clinical trial safety, by ensuring that the trial conduct is designed in an ethical manner (Wendler, Emanuel, & Lie, 2004). Most importantly, if the informed consent is not free of ambiguity or easily understood or translated correctly or interpreted appropriately to the subjects, the lack thereof, indicates

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