Selected gene–environment interactions observed in at least two studies

Gene|[ndash]|environment interactions in human diseases

Gene symbol ; Variant(s); Environmental exposure; Outcome and nature of interaction;

ADH1C, alcohol dehydrogenase 1C (class I), γ-polypeptide; ADRB2, adrenergic, ß-2-, receptor, surface; CCR5, chemokine (C–C motif) receptor 5; APOE, apolipoprotein E;F5, coagulation factor V; HIV, human immunodeficiency virus; HLA-DPB1, major histocompatibility complex, class II, DP ß-1; MC1R, melanocortin receptor 1;

MTHFR, 5,10-methylenetetrahydrofolate reductase (NADPH); NAT2, N-acetyltransferase 2;

PPARG2, peroxisome proliferative activated receptor-γ; TPMT, thiopurine S-methyltransferase; UGT1A6, UDP glycosyltransferase 1 family, polypeptide A6.

Reference

David J. Hunter .(2005). Selected examples of gene–environment interactions observed in at least two studies. Nature Reviews Genetics (6), 287-298. doi:10.1038/nrg1578. Retrieved from http://www.nature.com/nrg/journal/v6/n4/fig _tab/nrg1578_T3.html.