Gene VI is a multifunctional gene. Thus far, there are four known functions of gene VI in the viral infection cycle. Gene VI is associated with viral particles assembly. Secondly, Gene VI is an inhibitory machinery, a cellular anti-pathogen defense RNA silencer (Haas et al. 2008). Thirdly, Gene VI encodes active trans-activating long RNA (35S RNA) of a CaMV (Park et al. 2001). Fourthly, Gene VI disables an organism’s defense systems and make plants and other organisms susceptible to a bacterial pathogen (Love et al. 2012)

Reference

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Dunoyer P, and  O Voinnet (2006) The complex interplay between plant viruses and host RNA-   silencing pathways.  Curr Opinion in Plant Biology 8: 415–423.

Haas G, Azevedo J, Moissiard G, Geldreich A, Himber C, Bureau M, et al. (2008) Nuclear  import of CaMV P6 is required for infection and suppression of the RNA silencing factor     DRB4. EMBO J 27: 2102-12.

Latham, J & Wilson, A. (2013).  Regulators Discover a Hidden Viral Gene in Commercial GMO Crops. Retrieved from http://independentsciencenews.org/commentaries/   regulators-discover-a-hidden-viral-gene-in-commercial-gmo-crops/.

Love AJ , C Geri, J Laird, C Carr, BW Yun, GJ Loake et al (2012) Cauliflower mosaic virusProtein P6 Inhibits Signaling Responses to Salicylic Acid and Regulates Innate      Immunity. PLoS One. 7(10): e47535.

Podevin N and  du Jardin P (2012) Possible consequences of the overlap between the CaMV 35S promoter regions in plant transformation vectors used and the viral gene VI in transgenic plants. GM Crops and Food 3: 1-5.

Séralini, G-E., E. Clair, R. Mesnage, S. Gress, N. Defarge, M. Malatesta, D. Hennequin, J. Spiroux de Vendômois. 2012. Long term toxicity of a Roundup herbicide and aRoundup-tolerant genetically modified maize. Food Chem. Toxicol.